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. 2014:2014:173053.
doi: 10.1155/2014/173053. Epub 2014 Jun 25.

Prevalence of Multiple Antibiotic Resistant Infections in Diabetic versus Nondiabetic Wounds

Urvish Trivedi  1 , Shamini Parameswaran  1 , Andrew Armstrong  1 , Diana Burgueno-Vega  1 , John Griswold  2 , Sharmila Dissanaike  2 , Kendra P Rumbaugh  2
Affiliations

Prevalence of Multiple Antibiotic Resistant Infections in Diabetic versus Nondiabetic Wounds

Urvish Trivedi et al. J Pathog. 2014.

Abstract

Diabetes mellitus (DM) affects 23.6 million people in the USA and approximately 20-25% of diabetic patients will develop foot ulceration during the course of their disease. Up to a quarter of these patients will develop infections that will necessitate amputation. Although many studies report that the rates of antibiotic resistant infections have increased dramatically in the DM population over the last decade, to our knowledge there have been no reports directly comparing the rates of antibiotic resistant infections in DM versus non-DM wounds. We performed a retrospective study comparing the wound infections of 41 DM patients to those of 74 non-DM patients to test the hypothesis that infections with multidrug resistant organisms (MDRO) were more prevalent in the DM population. We found that 63.4% of DM and 50% of non-DM patients had MDRO infections, which was not statistically different. However, 61% of the DM patients had Pseudomonas infections compared to only 18.9% of non-DM patients. Furthermore, DM patients had significantly more coinfections with both Pseudomonas and Staphylococcus aureus. Though our initial hypothesis was incorrect, we demonstrated a significant correlation between Pseudomonas and Pseudomonas/S. aureus coinfections within DM wounds.

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Figures

Figure 1
Figure 1
Overall prevalence of MDRO and non-MDRO isolated from wounds.
Figure 2
Figure 2
Percent of  DM and non-DM patients with MDR- and non-MDR-Pseudomonas, -S. aureus, and -Enterococcus wound infections.
See this image and copyright information in PMC

References

    1. Prevention CfDCa. National Diabetes Fact Sheet: National Estimates and General Information on Diabetes and Prediabetes in the United States, 2011. Atlanta, Ga, USA: Department of Health and Human Services, Centers for Disease Control and Prevention; 2011.
    1. Enoch S, Williams D, Price P, Harding P, Moloney MC, Burke P. E. Randomized clinical trial and economic analysis of four-layer compression bandaging for venous ulcers. British Journal of Surgery. 2003;90(7):794–798. - PubMed
    1. Reiber GE. The epidemiology of diabetic foot problems. Diabetic Medicine. 1996;13(supplement 1):S6–S11. - PubMed
    1. Brem H, Sheehan P, Boulton AJ. Protocol for treatment of diabetic foot ulcers. The American Journal of Surgery. 2004;187(5A):1S–10S. - PubMed
    1. Ohsawa S, Inamori Y, Fukuda K, Hirotuji M. Lower limb amputation for diabetic foot. Archives of Orthopaedic and Trauma Surgery. 2001;121(4):186–190. - PubMed

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