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. 2014:2014:686392.
doi: 10.1155/2014/686392. Epub 2014 Jun 26.

Increased oxidative damage associated with unfavorable cytogenetic subgroups in chronic lymphocytic leukemia

Rosa Collado  1 , David Ivars  2 , Isabel Oliver  2 , Carmen Tormos  3 , Mercedes Egea  1 , Amparo Miguel  1 , Guillermo T Sáez  4 , Félix Carbonell  5
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Increased oxidative damage associated with unfavorable cytogenetic subgroups in chronic lymphocytic leukemia

Rosa Collado et al. Biomed Res Int. 2014.

Abstract

Oxidative stress contributes to genomic instability in chronic lymphocytic leukemia (CLL), but its relationship with the acquisition of specific chromosomal abnormalities is unknown. We recruited 55 untreated CLL patients and assessed 8-oxo-2'-deoxyguanosine (8-oxo-dG), glutathione, and malondialdehyde (MDA) levels, and we compared them among the cytogenetic subgroups established using fluorescence in situ hybridization (FISH). Significant increases in 8-oxo-dG and/or MDA were observed in patients with unfavorable cytogenetic aberrations (17p and 11q deletions) compared to the 13q deletion group. TP53 deletion patients exhibited a diminished DNA repair efficiency. Finally, cases with normal FISH also showed enhanced 8-oxo-dG, which could result in adverse outcomes.

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Figures

Figure 1
Figure 1
Analysis between cytogenetic subgroups with respect to (a) lymphocytes 8-oxo-dG/106 dG levels and (b) malondialdehyde-MDA levels. The mean value is shown for each group (bars). P values were determined on the basis of the Student's t-test.
See this image and copyright information in PMC

References

    1. Döhner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. The New England Journal of Medicine. 2000;343(26):1910–1916. - PubMed
    1. Haferlach C, Dicker F, Weiss T, et al. Toward a comprehensive prognostic scoring system in chronic lymphocytic leukemia based on a combination of genetic parameters. Genes Chromosomes and Cancer. 2010;49(9):851–859. - PubMed
    1. Puente XS, Pinyol M, Quesada V, et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature. 2011;475(7354):101–105. - PMC - PubMed
    1. Rossi D, Rasi S, Spina V, et al. Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia. Blood. 2013;121(8):1403–1412. - PMC - PubMed
    1. Landau DA, Carter SL, Stojanov P, et al. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell. 2013;152(4):714–726. - PMC - PubMed

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