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. 2014 Dec;33(12):2332-41.
doi: 10.1109/TMI.2014.2340135. Epub 2014 Jul 17.

Attenuation correction synthesis for hybrid PET-MR scanners: application to brain studies

Ninon Burgos, M Jorge Cardoso, Kris Thielemans, Marc Modat, Stefano Pedemonte, John Dickson, Anna Barnes, Rebekah Ahmed, Colin J Mahoney, Jonathan M Schott, John S Duncan, David Atkinson, Simon R Arridge, Brian F Hutton, Sebastien Ourselin

Attenuation correction synthesis for hybrid PET-MR scanners: application to brain studies

Ninon Burgos et al. IEEE Trans Med Imaging. 2014 Dec.

Abstract

Attenuation correction is an essential requirement for quantification of positron emission tomography (PET) data. In PET/CT acquisition systems, attenuation maps are derived from computed tomography (CT) images. However, in hybrid PET/MR scanners, magnetic resonance imaging (MRI) images do not directly provide a patient-specific attenuation map. The aim of the proposed work is to improve attenuation correction for PET/MR scanners by generating synthetic CTs and attenuation maps. The synthetic images are generated through a multi-atlas information propagation scheme, locally matching the MRI-derived patient's morphology to a database of MRI/CT pairs, using a local image similarity measure. Results show significant improvements in CT synthesis and PET reconstruction accuracy when compared to a segmentation method using an ultrashort-echo-time MRI sequence and to a simplified atlas-based method.

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