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. 2014 Oct;14(10):2400-5.
doi: 10.1111/ajt.12845. Epub 2014 Jul 23.

Paclitaxel-coated balloons in refractory nonanastomostic airway stenosis following lung transplantation

M Greer  1 , T Fuehner, G Warnecke, H Noack, T Heilmann, A Haverich, T Welte, J Gottlieb
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Free article

Paclitaxel-coated balloons in refractory nonanastomostic airway stenosis following lung transplantation

M Greer et al. Am J Transplant. 2014 Oct.
Free article

Abstract

Airway stenosis represents the commonest airway complication following lung transplantation, affecting between 7% and 18% of patients. Existing treatment options offer limited efficacy and can cause additional patient morbidity. Paclitaxel-coated balloons (PCB) have proved effective in managing postinterventional coronary artery re-stenosis. In a first-in-man study, we evaluated similar PCBs in refractory nonanastomotic airway stenosis in 12 patients. Following a single application, luminal patency was maintained in 50% at 270 days. No significant peri-interventional or early postinterventional complications occurred. Given these encouraging initial findings, further studies appear warranted.

Keywords: Clinical research/practice; comorbidities; complication; lung (allograft) function/dysfunction; lung transplantation/pulmonology.

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