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Comparative Study
. 2014 Oct;52(10):3777-80.
doi: 10.1128/JCM.01235-14. Epub 2014 Jul 23.

Comparison of amplicor and GeneXpert MTB/RIF tests for diagnosis of tuberculous meningitis

Vinod B Patel  1 , Cathy Connolly  2 , Ravesh Singh  3 , Laura Lenders  4 , Brian Matinyenya  4 , Grant Theron  4 , Thumbi Ndung'u  3 , Keertan Dheda  5
Affiliations
Comparative Study

Comparison of amplicor and GeneXpert MTB/RIF tests for diagnosis of tuberculous meningitis

Vinod B Patel et al. J Clin Microbiol. 2014 Oct.

Abstract

There are no data about the comparative accuracy of commercially available nucleic acid amplification tests (GeneXpert MTB/RIF and Roche Amplicor) for the diagnosis of tuberculous meningitis (TBM). A total of 148 patients with suspected TBM were evaluated, and cultures served as the reference standard. The sensitivities and specificities (95% confidence interval [CI]) for the Amplicor and Xpert MTB/RIF tests were similar: 46 (31-60) versus 50 (33-67) and 99 (93-100) and 94 (84-99), respectively.

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Figures

FIG 1
FIG 1
Summary of the study plan, sample processing, and outcome. +ve, positive; −ve, negative.
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