Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jul 13;5(7):585-9.
doi: 10.7150/jca.9785. eCollection 2014.

3.0T MR-CAD: Clinical Value in Diagnosis of Breast Tumor Compared with Conventional MRI

Yu-Hui Liu  1 , Liang Xu  1 , Li-Heng Liu  1 , Xiao-Shan Liu  1 , Zhong-Yu Hou  1 , Dong-Liang Hou  1 , Zhao-Qiu Chen  1 , Wen-Wu Li  1 , Yong Huang  1
Affiliations

3.0T MR-CAD: Clinical Value in Diagnosis of Breast Tumor Compared with Conventional MRI

Yu-Hui Liu et al. J Cancer. .

Abstract

Purpose: to explore the clinical value of 3.0T magnetic resonance (MR) imaging compared with computer-aided MR diagnosis (MR-CAD) in differential diagnosis of benign and malignant breast tumors.

Materials and methods: MRI method and MR-CAD method was used in the diagnosis of a total of 93 breast lesions of 78 patients, based on the morphological and time-intensity-curve (TIC) analysis. The accuracy of the two modalities in differentiating malignant and benign breast tumor was compared.

Results: MR-CAD method yielded a statistically better accuracy than MRI method. For 51 mass-like lesions, MRI and MR-CAD had no difference in diagnosing accuracy, but MR-CAD had better accuracy in 42 non-mass-like lesions.

Conclusion: MR-CAD had a notable advantage over MRI in differential diagnosis of benign and malignant breast tumors, especially non-mass-like tumor.

Keywords: 3.0T magnetic resonance imaging; computer-aided MR diagnosis.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Diagram showing the morphologic analysis procedure.
Figure 2
Figure 2
A patient with histologically proven infiltrative ductal carcinoma with a history of five years after right beast radical mastectomy. A non-mass-like lesion was identified in the inner upper quadrant of left breast, which was diagnosed as benign lesion based on morphological analysis by using dynamic contrast enhanced MRI (A~H indicating time serial dynamics) on workstation.
Figure 3
Figure 3
Same case with Figure 2. A diagnosis of malignant tumor was made by using MR-CAD, which revealed a good percentage of area of quick wash-in and wash-out within the lesion.
Figure 4
Figure 4
Diagram showing the time intensity curve (TIC) analysis procedure.
See this image and copyright information in PMC

References

    1. Zeng H, Zheng R, Zhang S, Zou X, Chen W. Incidence and mortality of female breast cancer in China, 2009. Thoracic Cancer. 2013;4(4):400–404. - PubMed
    1. Wiener JI, Schilling KJ, Adami C, Obuchowski NA. Assessment of suspected breast cancer by MRI: a prospective clinical trial using a combined kinetic and morphologic analysis. AJR Amer J Roen. 2005;184(3):878–886. - PubMed
    1. Jansen SA, Shimauchi A, Zak L. et al. Kinetic curves of malignant lesions are not consistent across MRI systems: need for improved standardization of breast dynamic contrast-enhanced MRI acquisition. Amer J Roen. 2009;193(3):832–839. - PMC - PubMed
    1. Comstock C. Breast magnetic resonance imaging interpretation using computer-aided detection. Sem Roen. 2011;46(1):76–85. - PubMed
    1. Lehman CD, Peacock S, DeMartini WB, Chen X. A new automated software system to evaluate breast MR examinations: improved specificity without decreased sensitivity. Amer J Roen. 2006;187(1):51–56. - PubMed