Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2014 May 6;5(6):2054270414527280.
doi: 10.1177/2054270414527280. eCollection 2014 Jun.

Thoracic amyloidomas: Two case reports of an evasive diagnosis

Rosie Cresner  1 , Shameem Mahmood  2 , Jane Chen  3 , Camilla Rowan  4 , Ashutosh D Wechalekar  2
Affiliations
Case Reports

Thoracic amyloidomas: Two case reports of an evasive diagnosis

Rosie Cresner et al. JRSM Open. .

Abstract

Amyloidosis is a rare differential diagnosis of a mass detected in the chest. Amyloidoma is caused by a local proliferation of clonal B-cells secreting an unstable immunoglobulin light chain which accumulates. FDG-PET scan are useful but not specific. Treatment is generally by local resection for treatment of symptoms. We report two cases of amyloidomas, which are rare entities characterised by large local amyloid deposits. These can occur in the upper respiratory tract, soft tissues and central nervous system.(1.)

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
FDG-PET/CT of right mediastinal mass in case 1.
Figure 2.
Figure 2.
FDG-PET/CT of multiple nodules in case 2.
See this image and copyright information in PMC

References

    1. Desai RA, Mahajan VK, Benjamin S, Van Ordstrand HS, Cordasco EM. Pulmonary amyloidoma and hilar adenopathy. Rare manifestations of primary amyloidosis. Chest 1979; 76: 170–173 - PubMed
    1. Pepys MB. Pathogenesis, diagnosis and treatment of systemic amyloidosis. Phil Trans R Soc Lond B Biol Sci 2001; 356: 203–211 - PMC - PubMed
    1. Rosenzweig M, Landau H. Light chain (AL) amyloidosis: update on diagnosis and management. J Hematol Oncol 2011; 4: 47–54 - PMC - PubMed
    1. Bennhold H. Specific staining of amyloid by Congo Red [in German]. Münchener Medizinische Wochenschrift 1922; 69: 1537–1538
    1. Gertz M, Comenzo R, Falk R, Fermand JP, Hazenberg BP, Hawkins PN, et al. Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis, Tours, France, 18–22 April 2004. Am J Hematol 2005; 79: 319–328 - PubMed

Publication types

LinkOut - more resources