Autologous hematopoietic stem cell therapy in severe systemic sclerosis: ready for clinical practice?

Affiliations

¹ Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor.
² Fred Hutchinson Cancer Research Center, University of Washington, Seattle.
³ Blood and Marrow Transplantation Program, Department of Internal Medicine, University of Michigan, Ann Arbor.

Editorial

Dinesh Khanna et al. JAMA. 2014.

. 2014 Jun 25;311(24):2485-7.

doi: 10.1001/jama.2014.6369.

¹ Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor.
² Fred Hutchinson Cancer Research Center, University of Washington, Seattle.
³ Blood and Marrow Transplantation Program, Department of Internal Medicine, University of Michigan, Ann Arbor.

Erratum in

No abstract available

Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial.
van Laar JM, Farge D, Sont JK, Naraghi K, Marjanovic Z, Larghero J, Schuerwegh AJ, Marijt EW, Vonk MC, Schattenberg AV, Matucci-Cerinic M, Voskuyl AE, van de Loosdrecht AA, Daikeler T, Kötter I, Schmalzing M, Martin T, Lioure B, Weiner SM, Kreuter A, Deligny C, Durand JM, Emery P, Machold KP, Sarrot-Reynauld F, Warnatz K, Adoue DF, Constans J, Tony HP, Del Papa N, Fassas A, Himsel A, Launay D, Lo Monaco A, Philippe P, Quéré I, Rich É, Westhovens R, Griffiths B, Saccardi R, van den Hoogen FH, Fibbe WE, Socié G, Gratwohl A, Tyndall A; EBMT/EULAR Scleroderma Study Group. van Laar JM, et al. JAMA. 2014 Jun 25;311(24):2490-8. doi: 10.1001/jama.2014.6368. JAMA. 2014. PMID: 25058083 Clinical Trial.

1. Nash RA, McSweeney PA, Crofford LJ, et al. High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study. Blood. 2007;110(4):1388–1396. - PMC - PubMed
1. Khanna D, Denton CP. Evidence-based management of rapidly progressing systemic sclerosis. Best Pract Res Clin Rheumatol. 2010 Jun;24(3):387–400. - PMC - PubMed
1. Varga J, Abraham D. Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest. 2007 Mar;117(3):557–567. - PMC - PubMed
1. Burt RK, Shah SJ, Dill K, et al. Autologous non-myeloablative haemopoietic stem-cell transplantation compared with pulse cyclophosphamide once per month for systemic sclerosis (ASSIST): an open-label, randomised phase 2 trial. Lancet. 2011 Aug 6;378(9790):498–506. - PubMed
1. Muraro PA, Robins H, Malhotra S, et al. T cell repertoire following autologous stem cell transplantation for multiple sclerosis. J Clin Invest. 2014 Mar 3;124(3):1168–1172. - PMC - PubMed