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. 2014 Aug 15;79(16):7752-7.
doi: 10.1021/jo501364b. Epub 2014 Jul 31.

Microwave-assisted cobinamide synthesis

Keith O Proinsias  1 , Maksymilian Karczewski, Anna Zieleniewska, Dorota Gryko
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Microwave-assisted cobinamide synthesis

Keith O Proinsias et al. J Org Chem. .

Abstract

We present a new method for the preparation of cobinamide (CN)2Cbi, a vitamin B12 precursor, that should allow its broader utility. Treatment of vitamin B12 with only NaCN and heating in a microwave reactor affords (CN)2Cbi as the sole product. The purification procedure was greatly simplified, allowing for easy isolation of the product in 94% yield. The use of microwave heating proved beneficial also for (CN)2Cbi(c-lactone) synthesis. Treatment of (CN)2Cbi with triethanolamine led to (CN)2Cbi(c-lactam).

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