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Comment
. 2014 Jul 25;345(6195):385-6.
doi: 10.1126/science.1258295.

Neuroscience. Astrocytes eyeball axonal mitochondria

Thomas C Burdett  1 , Marc R Freeman  2
Affiliations
Comment

Neuroscience. Astrocytes eyeball axonal mitochondria

Thomas C Burdett et al. Science. .
No abstract available

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Figures

None
Eye on mitochondria
Retinal ganglion cells in the optic nerve head of the mouse are enwrapped by astrocytes and rapidly turn over mitochondria to meet high metabolic demands.
None
Transmitophagy
Mitochondria cluster in the axon of a retinal ganglion cell in the optic nerve head. This forms an evulsion that is internalized by a nearby astrocyte. Mitochondria are then degraded in lysosomes.
See this image and copyright information in PMC

Comment on

  • Transcellular degradation of axonal mitochondria.
    Davis CH, Kim KY, Bushong EA, Mills EA, Boassa D, Shih T, Kinebuchi M, Phan S, Zhou Y, Bihlmeyer NA, Nguyen JV, Jin Y, Ellisman MH, Marsh-Armstrong N. Davis CH, et al. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9633-8. doi: 10.1073/pnas.1404651111. Epub 2014 Jun 16. Proc Natl Acad Sci U S A. 2014. PMID: 24979790 Free PMC article.

References

    1. Youle RJ, van der Bliek AM. Science. 2012;337:1062. - PMC - PubMed
    1. Sheng ZH. J Cell Biol. 2014;204:1087. - PMC - PubMed
    1. Davis CH, et al. Proc Natl Acad Sci USA. 2014;111:9633. - PubMed
    1. Smith DH. Prog Neurobiol. 2009;89:231. - PMC - PubMed
    1. Morrison BM, Lee Y, Rothstein JD. Trends Cell Biol. 2013;23:644. - PMC - PubMed

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