Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Oct;57(10):3254-6.
doi: 10.1128/iai.57.10.3254-3256.1989.

Beta interferon inhibits Toxoplasma gondii growth in human monocyte-derived macrophages

J L Schmitz  1 , J M Carlin, E C Borden, G I Byrne
Affiliations

Beta interferon inhibits Toxoplasma gondii growth in human monocyte-derived macrophages

J L Schmitz et al. Infect Immun. 1989 Oct.

Abstract

Gamma interferon (IFN-gamma) previously has been shown to block the replication of Toxoplasma gondii in fibroblasts by the induction of indoleamine 2,3-dioxygenase (IDO) activity. IFN-beta also is known to induce IDO activity in monocyte-derived macrophages, but its ability to block the growth of T. gondii has not been demonstrated. We found not only that the combination of IFN-beta and lipopolysaccharide induced greater IDO activity in monocyte-derived macrophages than did IFN-beta alone but that this combination also was effective in inhibiting the growth of T. gondii. In addition, the inhibition was reversed by the addition of exogenous tryptophan, thus demonstrating that a mechanism by which IFN-beta inhibited T. gondii replication was by the induction of IDO.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1984 Feb;81(3):908-12 - PubMed
    1. J Interferon Res. 1989 Jun;9(3):329-37 - PubMed
    1. J Immunol. 1983 Nov;131(5):2542-4 - PubMed
    1. J Chromatogr. 1979 Jul 13;175(2):343-6 - PubMed
    1. Infect Immun. 1986 Aug;53(2):347-51 - PubMed

Publication types

MeSH terms