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. 2014 Oct 28;353(2):201-10.
doi: 10.1016/j.canlet.2014.07.026. Epub 2014 Jul 22.

MicroRNA-370 suppresses proliferation and promotes endometrioid ovarian cancer chemosensitivity to cDDP by negatively regulating ENG

Xiao-Ping Chen  1 , You-Guo Chen  2 , Jian-Yun Lan  3 , Zong-Ji Shen  4
Affiliations

MicroRNA-370 suppresses proliferation and promotes endometrioid ovarian cancer chemosensitivity to cDDP by negatively regulating ENG

Xiao-Ping Chen et al. Cancer Lett. .

Abstract

MicroRNAs (miRNAs) are a class of non-coding RNAs that post-transcriptionally inhibit gene expression. In this study, we discovered that microRNA-370 (miR-370) was down-regulated in endometrioid ovarian cancer cells. In IGROV1 and TOV112D endometrioid ovarian cancer cells, miR-370 suppressed cellular viability and colony formation. miR-370 also enhanced endometrioid ovarian cancer cell chemosensitivity to cDDP. Endoglin (ENG) was directly and negatively regulated by miR-370. In addition, hypermethylation was a potential mechanism of miR-370 epigenetic silencing. We conclude that miR-370 acts as a tumor suppressor in endometrioid ovarian cancer via ENG regulation.

Keywords: Endoglin; Endometrioid ovarian cancer; MicroRNA; Target gene; miR-370.

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