Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Jul-Aug;81(4):312-6.

[Malignant mesothelioma risk factors: experience in the General Hospital of Mexico]

[Article in Spanish]
Alejandro Hernández-Solís  1 , Cyntia Garcia-Hernández  2 , Arturo Reding-Bernal  3 , Humberto Cruz-Ortiz  4 , Raúl Cicero-Sabido  3
Affiliations
  • PMID: 25063896

[Malignant mesothelioma risk factors: experience in the General Hospital of Mexico]

[Article in Spanish]
Alejandro Hernández-Solís et al. Cir Cir. 2013 Jul-Aug.

Abstract
in English, Spanish

Background: Malignant mesothelioma is a neoplasm of bad prognosis, it is linked with asbestos contact, but there are cases without this antecedent.

Objective: To investigate the relationship of asbestos exposition and other factors with malignant mesothelioma.

Methods: Retrospective analysis of histologic confirmed cases of malignant mesothelioma, neoplasic familiar history, tobacco smoking, exposure to wood smoke and to asbestos, were annotated in a paired case/control study 1: 1-3 with logistic regression model to identify risk factors for OR.

Results: 61 cases of malignant mesothelioma were confirmed by histopathologic study, 41 male and 20 female. Mean age was 56 years ± 13 years; 56 cases (91.8%) correspond to epithelial malignant mesothelioma, three sarcomatous (4.9%) one desmoplastic and one biphasic. One in eight (13.1%) had exposure to asbestos. Model of logistic regression with four variables: history of familiar cancer, tobacco smoking, wood smoke and asbestos exposition, the the last one with an OR= 3.083 and p > 0.05. No other variables found to be a risk factor for malignant mesothelioma.

Conclusions: Exposure to asbestos is a risk factor for malignant mesothelioma, which is confirmed in this study, however it is important to extend the investigation of other possible causal factors of this disease.

Antecedentes: el mesotelioma maligno es un tumor de mal pronóstico relacionado con el contacto con asbesto; sin embargo, existen numerosos casos sin este antecedente. Objetivo: describir la relación entre la exposición al asbesto y otros factores con el mesotelioma maligno. Material y métodos: estudio retrospectivo de casos y controles pareado 1: 1-3 por edad y sexo de pacientes con diagnóstico de mesotelioma maligno. Se registraron: la exposición al asbesto, tabaco, humo de leña y antecedentes familiares de cáncer. Se empleó regresión logística para razones de momios (ORs). Resultados: se estudiaron 61 casos con mesotelioma maligno, 41 hombres y 20 mujeres. La edad promedio fue 56 ± 13 años; 56 casos fueron mesotelioma maligno epitelial (91.8%), tres sarcomatosos (4.9%), uno desmoplásico y uno bifásico. Sólo en 8 (13.1%) se identificó exposición al asbesto. En el modelo de regresión logística el asbesto tuvo una razón de momios de 3.083 p > 0.05. Ninguna otra variable resultó ser un factor de riesgo para mesotelioma maligno. Conclusiones: la exposición al asbesto es un factor de riesgo para mesotelioma maligno, lo que se confirma en este estudio; sin embargo, es importante ampliar la investigación de otros posibles factores causales de esta enfermedad.

Keywords: Malignant mesothelioma; asbestos; humo de leña; mesotelioma maligno; wood smoke exposure.

PubMed Disclaimer

Similar articles

See all similar articles

MeSH terms

LinkOut - more resources