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Meta-Analysis
. 2014 Jul 27:15:122.
doi: 10.1186/1471-2369-15-122.

Is hyperuricemia an independent risk factor for new-onset chronic kidney disease?: A systematic review and meta-analysis based on observational cohort studies

Ling Li, Chen Yang, Yuliang Zhao, Xiaoxi Zeng, Fang Liu, Ping Fu  1
Affiliations
Meta-Analysis

Is hyperuricemia an independent risk factor for new-onset chronic kidney disease?: A systematic review and meta-analysis based on observational cohort studies

Ling Li et al. BMC Nephrol. .

Abstract

Background: Hyperuricemia has been reported to be associated with chronic kidney disease (CKD). However whether an elevated serum uric acid level is an independent risk factor for new-onset CKD remained controversial.

Methods: A systematic review and meta-analysis using a literature search of online databases including PubMed, Embase, Ovid and ISI Web/Web of Science was conducted. Summary adjusted odds ratios with corresponding 95% confidence intervals (95% CI) were calculated to evaluate the risk estimates of hyperuricemia for new-onset CKD.

Results: Thirteen studies containing 190,718 participants were included. A significant positive association was found between elevated serum uric acid levels and new-onset CKD at follow-up (summary OR, 1.15; 95% CI, 1.05-1.25). Hyperuricemia was found be an independent predictor for the development of newly diagnosed CKD in non-CKD patients (summary OR, 2.35; 95% CI, 1.59-3.46). This association increased with increasing length of follow-up. No significant differences were found for risk estimates of the associations between elevated serum uric acid levels and developing CKD between males and females.

Conclusions: With long-term follow-up of non-CKD individuals, elevated serum uric acid levels showed an increased risk for the development of chronic renal dysfunction.

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Figures

Figure 1
Figure 1
Study flow diagram of study selection.
Figure 2
Figure 2
Forest plot of association between SUA and new-onset CKD.
Figure 3
Figure 3
Forest plot of association between SUA and new-onset CKD (excluding the study by Chang et al. [[17]]).
Figure 4
Figure 4
Forest plot of association between hyperuricemia and new-onset CKD.
Figure 5
Figure 5
Forest plot of association between SUA and new-onset CKD in different genders.
Figure 6
Figure 6
Funnel plot of association between increasing SUA or hyperuricemia and new-onset CKD. a. Funnel plot of association between increasing SUA and new-onset CKD, b. Funnel plot of association between hyperuricemia and new-onset CKD.
See this image and copyright information in PMC

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