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Multicenter Study
. 2014 Oct;70(10):1237-42.
doi: 10.1007/s00228-014-1722-x. Epub 2014 Jul 29.

Consequences of dextropropoxyphene market withdrawal in elderly patients with chronic pain

Laurent Becquemont  1 , Tiba Delespierre, Bernard Bauduceau, Linda Benattar-Zibi, Gilles Berrut, Emmanuelle Corruble, Nicolas Danchin, Geneviève Derumeaux, Jean Doucet, Bruno Falissard, Francoise Forette, Olivier Hanon, Florence Pasquier, Michel Pinget, Rissane Ourabah, Sophie Bucher, Aida Lazkani, Celine Piedvache, Philippe Bertin
Affiliations
Multicenter Study

Consequences of dextropropoxyphene market withdrawal in elderly patients with chronic pain

Laurent Becquemont et al. Eur J Clin Pharmacol. 2014 Oct.

Abstract

Objective: Describe the consequences of dextropropoxyphene (DXP) market withdrawal on analgesic prescriptions and on the quality of therapeutic management of chronic pain.

Patients and methods: From a cohort of non-institutionalised elderly patients with chronic pain recruited by general practitioners, we selected patients who were treated with DXP daily for at least 6 months just prior to DXP market withdrawal and who had an evaluation of pain and its impact on daily activities before and after DXP withdrawal.

Results: One hundred three patients took DXP daily for chronic pain. Immediately after DXP market withdrawal, 42 (40.8%), 55 (53.4%) and 3 (2.9%) patients were treated with step 1, 2 and 3 analgesics, respectively, and 3 patients (2.9%) were no longer receiving any analgesic medication. Among the 55 patients who continued on step 2 analgesics, 37 were treated with tramadol, 14 with codeine and 9 with opium. Pain intensity and the impact of pain on daily activities remained stable.

Conclusion: DXP market withdrawal had no consequences on the intensity or impact of chronic pain in elderly patients.

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