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Comment
. 2014 Jul 28:15:125.
doi: 10.1186/1471-2369-15-125.

Additional perspectives on chronic kidney disease of unknown aetiology (CKDu) in Sri Lanka--lessons learned from the WHO CKDu population prevalence study

Jennifer Hoponick Redmon  1 , Myles F Elledge, Donna S Womack, Rajitha Wickremashinghe, Kamani P Wanigasuriya, Roshini J Peiris-John, Joseph Lunyera, Kristin Smith, James H Raymer, Keith E Levine
Affiliations
Comment

Additional perspectives on chronic kidney disease of unknown aetiology (CKDu) in Sri Lanka--lessons learned from the WHO CKDu population prevalence study

Jennifer Hoponick Redmon et al. BMC Nephrol. .

Abstract

The recent emergence of an apparently new form of chronic kidney disease of unknown aetiology (CKDu) has become a serious public health crisis in Sri Lanka. CKDu is slowly progressive, irreversible, and asymptomatic until late stages, and is not attributable to hypertension, diabetes, or other known aetiologies. In response to the scope and severity of the emerging CKDu health crisis, the Sri Lanka Ministry of Health and the World Health Organization initiated a collaborative research project from 2009 through 2012 to investigate CKDu prevalence and aetiology. The objective of this paper is to discuss the recently published findings of this investigation and present additional considerations and recommendations that may enhance subsequent investigations designed to identify and understand CKDu risk factors in Sri Lanka or other countries.

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  • Response.
    Mendis S. Mendis S. BMC Nephrol. 2014;15:125. BMC Nephrol. 2014. PMID: 25147882 No abstract available.

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References

    1. Athuraliya NTC, Abeysekera TDJ, Amerasinghe PH, Kumarasiri R, Bandara P, Karunaratne U, Milton AH, Jones AL. Uncertain etiologies of proteinuric-chronic kidney disease in rural Sri Lanka. Kidney Int. 2011;80:1212–1221. - PubMed
    1. Senevirathna L, Abeysekara T, Nanayakkara S, Chandrajith R, Ratnatunga N, Harada K, Hitomi T, Komiya T, Muso E, Koizumi A. Risk factors associated with disease progression and mortality in chronic kidney disease of uncertain etiology: a cohort study in Medawachchiya, Sri Lanka. Environ Health Prev Med. 2012;17:191–198. - PMC - PubMed
    1. Peiris-John RJ, Wanigasuriya JKP, Wickremasinghe AR, Dissanayake WP, Hittarage A. Exposure to acetylcholinesterase-inhibiting pesticides and chronic renal failure. Ceylon Med J. 2006;51(1):42–43. - PubMed
    1. Wanigasuriya KP, Peiris H, Ileperuma N, Peiris-John RJ, Wickremasinghe R. Could ochratoxin a in food commodities be the cause of chronic kidney disease in Sri Lanka? Trans R Soc Trop Med Hyg. 2008;102:726–728. - PubMed
    1. Bandara JMRS, Wijewardena HVP, Liyanege J, Upul MA, Bandara JMUA. Chronic renal failure in Sri Lanka caused by elevated dietary cadmium: trojan horse of the green revolution. Toxicol Lett. 2010;198:33–39. - PMC - PubMed