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. 2014;78(11):1906-9.
doi: 10.1080/09168451.2014.940834. Epub 2014 Jul 29.

Manno-oligosaccharide-binding ability of mouse RegIV/GST-fusion protein evaluated by complex formation with the carbohydrate-containing polyamidoamine dendrimer

Yuta Kato  1 , Kazunori Kochi, Hideaki Unno, Shuichiro Goda, Tomomitsu Hatakeyama
Affiliations

Manno-oligosaccharide-binding ability of mouse RegIV/GST-fusion protein evaluated by complex formation with the carbohydrate-containing polyamidoamine dendrimer

Yuta Kato et al. Biosci Biotechnol Biochem. 2014.

Abstract

The carbohydrate-binding properties of the C-type lectin-like mouse RegIV and glutathione S-transferase-fusion protein (GST-mRegIV) were examined using carbohydrate-containing polyamidoamine dendrimers (PD). GST-mRegIV showed affinity for mannan- and manno-oligosaccharide containing PD. Binding was inhibited by manno-oligosaccharides but not by mannose or other tested carbohydrates, suggesting that the binding site may have an extended structure in contrast with typical C-type lectins.

Keywords: RegIV; binding; light scattering; mannose; polyamidoamine dendrimer.

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