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. 2014 Sep 1;120(17):2742-50.
doi: 10.1002/cncr.28670. Epub 2014 Jul 28.

Lifestyle and metabolic syndrome in adult survivors of childhood cancer: a report from the St. Jude Lifetime Cohort Study

Webb A Smith  1 , Chenghong Li, Kerri A Nottage, Daniel A Mulrooney, Gregory T Armstrong, Jennifer Q Lanctot, Wassim Chemaitilly, Joseph H Laver, Deo Kumar Srivastava, Leslie L Robison, Melissa M Hudson, Kirsten K Ness
Affiliations

Lifestyle and metabolic syndrome in adult survivors of childhood cancer: a report from the St. Jude Lifetime Cohort Study

Webb A Smith et al. Cancer. .

Abstract

Background: Childhood cancer survivors (CCS) are at an increased risk of developing metabolic syndrome (MetSyn), which may be reduced with lifestyle modifications. The purpose of this investigation was to characterize lifestyle habits and associations with MetSyn among CCS.

Methods: CCS who were ≥ 10 years from diagnosis, aged > 18 years, and participating in the St. Jude Lifetime Cohort Study completed medical and laboratory tests and a food frequency questionnaire. The Third Report of the National Cholesterol Education Program Adult Treatment Panel criteria were used to classify participants with MetSyn. Anthropometric, food frequency questionnaire, and self-reported physical activity data were used to characterize lifestyle habits according to World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations. Those who met ≥ 4 of 7 recommendations were classified as having followed guidelines. Sex-stratified log-binomial regression models were used to evaluate associations between dietary/lifestyle habits and MetSyn, adjusted for age, age at cancer diagnosis, receipt of cranial radiotherapy, education, and household income.

Results: Among 1598 CCS (49.2% of whom were male, with a median age of 32.7 years [range, 18.9 years-60.0 years]), 31.8% met criteria for MetSyn and 27.0% followed WCRF/AICR guidelines. Females who did not follow WCRF/AICR guidelines were 2.4 times (95% confidence interval, 1.7-3.3) and males were 2.2 times (95% confidence interval, 1.6-3.0) more likely to have MetSyn than those who followed WCRF/AICR guidelines.

Conclusions: Adherence to a heart-healthy lifestyle is associated with a lower risk of MetSyn among CCS. There is a need to determine whether lifestyle interventions prevent or remediate MetSyn in CCS.

Keywords: childhood cancer survivor; dietary intake; healthy lifestyle; metabolic syndrome.

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Figures

Figure 1
Figure 1
Consort Diagram as of October 31st, 2012.
Figure 2
Figure 2. Dietary status among participants with metabolic syndrome or metabolic syndrome components
Metabolic Syndrome and Components by Dietary Status. The light gray portion of the bar indicates the percentage of those who have metabolic syndrome and who did not follow WCRF/ACIR guidelines. The dark gray portion of the bar indicates the percentage who have metabolic syndrome and who follow WCRF/ACIR guidelines.
See this image and copyright information in PMC

References

    1. Howlader N, Noone AM, Krapcho M, Neyman N, Aminou R, Altekruse SF, Kosary CL, Ruhl J, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewis DR, Chen HS, Feuer EJ, Cronin KA, editors. SEER Cancer Statistics Review, 1975–2009 (Vintage 2009 Populations) 2012.
    1. Oeffinger KC, Mertens AC, Sklar CA, et al. Chronic Health Conditions in Adult Survivors of Childhood Cancer. N Engl J Med. 2006;355(15):1572–1582. - PubMed
    1. Mariotto AB, Rowland JH, Yabroff KR, et al. Long-Term Survivors of Childhood Cancers in the United States. Cancer Epidemiol Biomarkers Prev. 2009;18(4):1033–1040. - PubMed
    1. Oeffinger KC, Buchanan GR, Eshelman DA, et al. Cardiovascular Risk Factors in Young Adult Survivors of Childhood Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2001;23(7):424–430. - PubMed
    1. Oeffinger KC, Mertens AC, Sklar CA, et al. Chronic Health Conditions in Adult Survivors of Childhood Cancer. N Engl J Med. 2006;355(15):1572–1582. - PubMed

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