Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Jul 28;211(8):1500.
doi: 10.1084/jem.2118insight1.

Macrophages derived from infiltrating monocytes mediate autoimmune myelin destruction

Michael T Heneka  1
Affiliations
Comment

Macrophages derived from infiltrating monocytes mediate autoimmune myelin destruction

Michael T Heneka. J Exp Med. .
No abstract available

PubMed Disclaimer

Figures

None
Insight from Michael Heneka
None
Nodes of Ranvier represent a prime site of attack for MDMs at the onset of EAE. This 3D reconstruction of SBF-SEM images shows a monocyte-derived macrophage encircling the node of Ranvier, as shown by the two primary processes (white and black arrows).
See this image and copyright information in PMC

Comment on

  • Differential roles of microglia and monocytes in the inflamed central nervous system.
    Yamasaki R, Lu H, Butovsky O, Ohno N, Rietsch AM, Cialic R, Wu PM, Doykan CE, Lin J, Cotleur AC, Kidd G, Zorlu MM, Sun N, Hu W, Liu L, Lee JC, Taylor SE, Uehlein L, Dixon D, Gu J, Floruta CM, Zhu M, Charo IF, Weiner HL, Ransohoff RM. Yamasaki R, et al. J Exp Med. 2014 Jul 28;211(8):1533-49. doi: 10.1084/jem.20132477. Epub 2014 Jul 7. J Exp Med. 2014. PMID: 25002752 Free PMC article.

References

    1. Yamasaki, R., et al. . 2014. J. Exp. Med. 10.1084/jem.20132477. - DOI