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Review
. 2014 Jul 4:5:337.
doi: 10.3389/fmicb.2014.00337. eCollection 2014.

Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus

Selmir Avdic  1 , Brian P McSharry  1 , Barry Slobedman  2
Affiliations
Review

Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus

Selmir Avdic et al. Front Microbiol. .

Abstract

Human cytomegalovirus (HCMV), a clinically important β-herpesvirus, is a master of evasion and modulation of the host immune system, including inhibition of a number of dendritic cell (DC) functions. DCs play a central role in co-ordination of the immune response against pathogens and any disturbance of DCs functions can result in a cascade effect on a range of immune cells. Recently, the HCMV gene UL111A, which encodes viral homologs of human interleukin 10, has been identified as a strong suppressor of a number of DCs functions. In this mini review, we focus on HCMV-encoded viral IL-10-mediated inhibitory effects on DCs and implications for the development of an effective HCMV vaccine.

Keywords: cytomegalovirus; dendritic cells; immunomodulation; interleukin 10; virus replication and latency.

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References

    1. Ahn K., Gruhler A., Galocha B., Jones T. R., Wiertz E. J., Ploegh H. L., et al. (1997). The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. Immunity 6 613–621 10.1016/S1074-7613(00)80349-0 - DOI - PubMed
    1. Avdic S., Cao J. Z., Cheung A. K., Abendroth A., Slobedman B. (2011). Viral interleukin-10 expressed by human cytomegalovirus during the latent phase of infection modulates latently infected myeloid cell differentiation. J. Virol. 85 7465–7471 10.1128/JVI.00088-11 - DOI - PMC - PubMed
    1. Avdic S., Cao J. Z., Mcsharry B. P., Clancy L. E., Brown R., Steain M., et al. (2013). Human cytomegalovirus interleukin-10 polarizes monocytes toward a deactivated M2c phenotype to repress host immune responses. J. Virol. 87 10273–10282 10.1128/JVI.00912-13 - DOI - PMC - PubMed
    1. Brockman M. A., Kwon D. S., Tighe D. P., Pavlik D. F., Rosato P. C., Sela J., et al. (2009). IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood 114 346–356 10.1182/blood-2008-12-191296 - DOI - PMC - PubMed
    1. Caux C., Vanbervliet B., Massacrier C., Dezutter-Dambuyant C., De Saint-Vis B., Jacquet C., et al. (1996). CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha. J. Exp. Med. 184 695–706 10.1084/jem.184.2.695 - DOI - PMC - PubMed