Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Jul 9:4:172.
doi: 10.3389/fonc.2014.00172. eCollection 2014.

The yin-yang of microvesicles (exosomes) in cancer biology

Khalid Al-Nedawi  1
Affiliations
Review

The yin-yang of microvesicles (exosomes) in cancer biology

Khalid Al-Nedawi. Front Oncol. .
No abstract available

Keywords: PTEN; exosomes; metastasis; microvessels; progression.

PubMed Disclaimer

References

    1. Al-Nedawi K, Meehan B, Kerbel RS, Allison AC, Rak J. Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR. Proc Natl Acad Sci U S A (2009) 106:3794–910.1073/pnas.0804543106 - DOI - PMC - PubMed
    1. Skog J, Wurdinger T, van Rijn S, Meijer DH, Gainche L, Sena-Esteves M, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumor growth and provide diagnostic biomarkers. Nat Cell Biol (2008) 10:1470–610.1038/ncb1800 - DOI - PMC - PubMed
    1. Al-Nedawi K, Meehan B, Micallef J, Lhotak V, May L, Guha A, et al. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol (2008) 10:619–2410.1038/ncb1725 - DOI - PubMed
    1. Gabriel K, Ingram A, Austin R, Kapoor A, Tang D, Majeed F, et al. Regulation of the tumor suppressor PTEN through exosomes: a diagnostic potential for prostate cancer. PLoS One (2013) 8:e70047.10.1371/journal.pone.0070047 - DOI - PMC - PubMed
    1. Putz U, Howitt J, Doan A, Goh CP, Low LH, Silke J, et al. The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells. Sci Signal (2012) 5:ra70.10.1126/scisignal.2003084 - DOI - PubMed