Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Nov 15;32(7):1245-1255.
doi: 10.1016/j.biotechadv.2014.07.003. Epub 2014 Jul 27.

Advances in in-situ product recovery (ISPR) in whole cell biotechnology during the last decade

Wouter Van Hecke  1 , Guneet Kaur  2 , Heleen De Wever  3
Affiliations
Review

Advances in in-situ product recovery (ISPR) in whole cell biotechnology during the last decade

Wouter Van Hecke et al. Biotechnol Adv. .

Abstract

The review presents the state-of-the-art in the applications of in-situ product recovery (ISPR) in whole-cell biotechnology over the last 10years. It summarizes various ISPR-integrated fermentation processes for the production of a wide spectrum of bio-based products. A critical assessment of the performance of various ISPR concepts with respect to the degree of product enrichment, improved productivity, reduced process flows and increased yields is provided. Requirements to allow a successful industrial implementation of ISPR are also discussed. Finally, supporting technologies such as online monitoring, mathematical modeling and use of recombinant microorganisms with ISPR are presented.

Keywords: ISPR-coupled whole-cell bioprocess; In-situ product recovery (ISPR); Microbial biotransformations.

PubMed Disclaimer

Publication types

MeSH terms

Substances