Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Jul 28;30(2):111-2.
doi: 10.1016/j.devcel.2014.07.013.

Mother centrioles do a cartwheel to produce just one daughter

Jieyan V Chen  1 , Timothy L Megraw  2
Affiliations
Comment

Mother centrioles do a cartwheel to produce just one daughter

Jieyan V Chen et al. Dev Cell. .

Abstract

In this issue of Developmental Cell, Fong et al. (2014) present evidence for a model of centriole duplication whereby the cartwheel-the starting building block in centriole biogenesis-assembles within the lumen of the mother centriole before templating the daughter centriole to ensure a single duplication event per cell cycle.

PubMed Disclaimer

Figures

Figure 1
Figure 1. New model for centriole duplication
In this model, the cartwheel (purple) is preassembled in the lumen of the mother centriole (gold)in a CPAP/SAS-4-dependent manner during S phase. This scaffold is then transferred to the outside surface of the mother through PLK4 and STIL/SAS-5 to initiate daughter centriole assembly. The nascent, engaged daughter centriole blocks additional cartwheel preassembly in the mother, preventing further duplication. Illustration by Jodi Slade.
See this image and copyright information in PMC

Comment on

References

    1. Azimzadeh J, Marshall WF. Curr Biol. 2010;20(18):R816–25. - PMC - PubMed
    1. Brito DA, Gouveia SM, Bettencourt-Dias M. Curr Opin Cell Biol. 2012;24(1):4–13. - PubMed
    1. Fong CS, Kim M, Yang TT, Liao JC, Tsou MFB. Dev Cell. 2014:30. this issue. - PMC - PubMed
    1. Gottardo M, Callaini G, Riparbelli MG. J Cell Sci. 2014:127. - PubMed
    1. Kleylein-Sohn J, Westendorf J, Le Clech M, Habedanck R, Stierhof YD, Nigg EA. Dev Cell. 2007;13(2):190–202. - PubMed

LinkOut - more resources