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. 2014 Sep;38(9):1020-4.
doi: 10.1016/j.leukres.2014.05.001. Epub 2014 May 14.

Predictive factors for a single successful cytapheresis session during the first mobilisation

A C Gac  1 , J J Parienti  2 , S Chantepie  3 , S Cheze  3 , H Johnson-Ansah  3 , K Benabed  3 , M Macro  3 , V Lefevre  4 , A Batho  4 , C Fruchart  5 , O Reman  3
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Predictive factors for a single successful cytapheresis session during the first mobilisation

A C Gac et al. Leuk Res. 2014 Sep.

Abstract

To avoid repeated apheresis, the objective of this study was to analyse the predictive factors for a single successful cytapheresis during the first mobilisation. The pre-collection characteristics of 170 lymphoma and 95 myeloma patients were analysed. Among 60 lymphoma patients who had less than 30 CD34 cells/mm(3) the day before the first apheresis, an increase in the CD34 cell count between Day -1 and Day 1 was predictive of first stem cell mobilisation success, with a sensitivity of 100% if the Day 1 was higher than 30/mm(3) (10/60 patients). Success rate of obtaining an appropriate number of stem cells in one apheresis was 120 among 170 patients.

Keywords: Lymphoma; Multiple myeloma; Plerixafor; Single apheresis; Stem cell mobilisation.

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