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. 2014 Dec 1;171(12):1320-7.
doi: 10.1176/appi.ajp.2014.14010067. Epub 2014 Oct 31.

Glutamate metabolism in major depressive disorder

Chadi G Abdallah  1 , Lihong Jiang, Henk M De Feyter, Madonna Fasula, John H Krystal, Douglas L Rothman, Graeme F Mason, Gerard Sanacora
Affiliations

Glutamate metabolism in major depressive disorder

Chadi G Abdallah et al. Am J Psychiatry. .

Abstract

Research on novel treatments for major depressive disorder focuses quite deeply on glutamate function, and this research would benefit from a brain-imaging technique that precisely quantified glutamate function. Signs of a specific form of glutamate-related dysfunction that could be targeted by novel therapies were found using novel, state-of-the-art techniques to address this issue.

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Figures

Figure 1
Figure 1
13C MRS Voxel, Spectrum, and Time Courses. (A) Coils and voxels placement. (B) Spectrum acquired over 10 minutes at 4T from the occipital region during [1-13C]-glucose infusion at steady state. (C) Time courses from one participant showing the percent enrichment for each metabolite.
Figure 2
Figure 2
Mitochondrial Energy Production In MDD and Healthy Control
See this image and copyright information in PMC

Comment in

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