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. 2014 Aug;20(8):1315-8.
doi: 10.3201/eid2008.140339.

Novel reassortant influenza A(H5N8) viruses in domestic ducks, eastern China

Haibo Wu, Xiaorong Peng, Lihua Xu, Changzhong Jin, Linfang Cheng, Xiangyun Lu, Tiansheng Xie, Hangping Yao, Nanping Wu

Novel reassortant influenza A(H5N8) viruses in domestic ducks, eastern China

Haibo Wu et al. Emerg Infect Dis. 2014 Aug.

Abstract

Domestic ducks are natural reservoirs of avian influenza viruses and serve as reassortant hosts for new virus subtypes. We isolated 2 novel influenza A(H5N8) viruses from domestic ducks in eastern China, sequenced their genomes, and tested their pathogenicity in chickens and mice. Circulation of these viruses may pose health risks for humans.

Keywords: H5N8 subtype; avian influenza virus; domestic ducks; eastern China; influenza; influenza virus; poultry; virus reassortment; viruses.

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Figures

Figure 1
Figure 1
Phylogenetic analysis of A) hemagglutinin (HA) (nucleotide positions 9–1647) and B) neuraminidase (NA) (nucleotide positions 44–1381) genes of novel influenza A(H5N8) viruses isolated from domestic ducks, eastern China, 2013, and other influenza viruses. The tree was created by the using the neighbor-joining method and bootstrapped with 1,000 replicates by using MEGA 5.05 (http://www.megasoftware.net/). Influenza A(H5N8) viruses from China identified in this study are indicated by solid triangles, another influenza A(H5N8) virus from China is indicated by a white triangle, 3 influenza A(H5N8) viruses from South Korea (2014) are indicated by dots, and a novel influenza A(H10N8) virus (2013) that caused human infection is indicated by a diamond. Scale bars indicate distance units between sequence pairs.
Figure 2
Figure 2
Putative genomic compositions of novel influenza A(H5N8) viruses isolated from poultry, eastern China, 2013, and their 3 possible parent viruses. The 8 gene segments (from top to bottom) in each virus are basic polymerase 2, basic polymerase 1, acidic polymerase, hemagglutinin, nucleoprotein, neuramindase, matrix, and nonstructural protein. Each color represents a separate virus background: purple indicates Hunan/8-19 (H4N2); A/duck/Hunan/8–19/2009(H4N2); blue indicates k1203 (H5N8), A/duck/Jiangsu/k1203/2010(H5N8); and yellow indicates Jiangxi/28 (H11N9), A/environment/Jiangxi/28/2009(H11N9). The simplified schematic illustration is based on nucleotide-distance comparison and phylogenetic analysis.
See this image and copyright information in PMC

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