Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Jul 16:4:185.
doi: 10.3389/fonc.2014.00185. eCollection 2014.

Carbohydrate-mediated modulation of NK cell receptor function: structural and functional influences of heparan sulfate moieties expressed on NK cell surface

Michael Brusilovsky  1 , Olga Radinsky  1 , Rami Yossef  1 , Kerry S Campbell  2 , Angel Porgador  3
Affiliations
Review

Carbohydrate-mediated modulation of NK cell receptor function: structural and functional influences of heparan sulfate moieties expressed on NK cell surface

Michael Brusilovsky et al. Front Oncol. .
No abstract available

Keywords: KIR2DL4; NKp30; NKp44; NKp46; heparan sulfate; heparan sulfate proteoglycans; natural cytotoxicity receptors; natural killer cells.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Model of NK-function autoregulation by HSPG. Interaction of NKR with the HSPG on the NK cell surface: NKR can be recycled back to the cell surface, promote signaling or destined for degradation. If cells are exposed to ligand stimulation, this displaces HSPG from interacting and NKR is instead available to promote signaling and then can be recycled, or destined for degradation.
See this image and copyright information in PMC

References

    1. Sasisekharan R, Shriver Z, Venkataraman G, Narayanasami U. Roles of heparan-sulphate glycosaminoglycans in cancer. Nat Rev Cancer (2002) 2:521–8 10.1038/nrc842 - DOI - PubMed
    1. Hecht ML, Rosental B, Horlacher T, Hershkovitz O, De Paz JL, Noti C, et al. Natural cytotoxicity receptors NKp30, NKp44 and NKp46 bind to different heparan sulfate/heparin sequences. J Proteome Res (2009) 8:712–20 10.1021/pr800747c - DOI - PubMed
    1. Sasisekharan R, Venkataraman G. Heparin and heparan sulfate: biosynthesis, structure and function. Curr Opin Chem Biol (2000) 4:626–31 10.1016/S1367-5931(00)00145-9 - DOI - PubMed
    1. Esko JD, Lindahl U. Molecular diversity of heparan sulfate. J Clin Invest (2001) 108:169–73 10.1172/JCI13530 - DOI - PMC - PubMed
    1. Sanderson RD, Yang Y, Kelly T, Macleod V, Dai Y, Theus A. Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies. J Cell Biochem (2005) 96:897–905 10.1002/jcb.20602 - DOI - PubMed