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Case Reports
. 2014 Jul;6(7):342-5.
doi: 10.4103/1947-2714.136920.

Sarcomatoid carcinoma of the lung: a model of resistance of chemotherapy

Imane Ouziane  1 , Saber Boutayeb  2 , Hind Mrabti  2 , Issam Lalya  2 , Mouna Rimani  3 , Hassan Errihani  2
Affiliations
Case Reports

Sarcomatoid carcinoma of the lung: a model of resistance of chemotherapy

Imane Ouziane et al. N Am J Med Sci. 2014 Jul.

Abstract

Context: Lung tumors are very heterogeneous histological entities. Pulmonary sarcomatoid carcinoma is a subset of tumors characterized by specific histological features. Their poor prognosis compared to other lung tumors is due to limited responses to different types of chemotherapy.

Case report: WE REPORT TWO PATIENTS WITH SARCOMATOID TUMORS: A 53-year-old woman and a 46-year-old man who presented respiratory symptoms: Dyspnea, cough, associated with a deterioration of general condition.

Conclusion: Pulmonary sarcomatoid carcinomas remained an unexplored entity, despite their poor prognosis. Based on these cases, we will discuss the histological and immunohistochemical features of these tumors, as well as report their responses to different chemotherapy regimens used in the course of treatment.

Keywords: Chemotherapy; lung; response to platinum salts; saromatoid carcinoma; surgery; targeted therapy.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Chest CT scan showing a right cervicothoracic mass with vascular sheathing
Figure 2
Figure 2
(a) H&E staining G× 200 carcinomatous proliferation of pleomorphic spindle and globoid cells (b) H&E staining G× 400: Tumor cells expressing the vimentin antibody (clone V9, IMMUNOTEC) (c) H&E staining G× 400: Tumor cells expressing the CK (clone AE1/AE3, DAKO) (+) and thyroid transcription factor-1 (TTF1) (clone 8G7G3 / 1 DAKO (flex). Nuclear staining (+)
See this image and copyright information in PMC

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