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Comment
. 2014 Jul 31;10(7):e1003758.
doi: 10.1371/journal.pcbi.1003758. eCollection 2014 Jul.

Comments on "Human dominant disease genes are enriched in paralogs originating from whole genome duplication"

Wei-Hua Chen  1 , Xing-Ming Zhao  2 , Vera van Noort  1 , Peer Bork  3
Affiliations
Comment

Comments on "Human dominant disease genes are enriched in paralogs originating from whole genome duplication"

Wei-Hua Chen et al. PLoS Comput Biol. .
No abstract available

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Conflict of interest statement

This Formal Comment is a response to Singh et al., “Human Dominant Disease Genes are Enriched in Paralogs Originating from Whole Genome Duplication,” by the authors of the original research article “Human Monogenic Disease Genes Have Frequently Functionally Redundant Paralogs.”

Figures

Figure 1
Figure 1. Enrichment of MDs in old SSDs and distinct characteristics of the old SSDs as compared with the young ones.
Statistics using data from Singh et al. P-values and ORs (odd ratios) are calculated using Fisher's Exact Test (see Dataset S1 for the R code). A. MDs genes are enriched in old duplicates; left: percentage of old SSDs in MDs, right: percentage of old SSDs in all genes. B. Recessive MDs genes are enriched in old SSDs; left: percentage of old SSDs in recessive MDs, right: percentage of old SSDs in all MDs. C. Essential genes are depleted in young SSDs; left: percentage of young SSDs that are essential, right: percentage of young SSDs in tested genes. D. Essential genes are enriched in old SSDs; left: percentage of old SSDs that are essential, right: percentage of old SSDs in tested genes.
See this image and copyright information in PMC

Comment on

References

    1. Chen W-H, Zhao X-M, van Noort V, Bork P (2013) Human Monogenic Disease Genes Have Frequently Functionally Redundant Paralogs. PLoS Comput Biol 9: e1003073. - PMC - PubMed
    1. Singh PP, Affeldt S, Malaguti G, Isambert H (2014) Human Dominant Disease Genes are Enriched in Paralogs Originating from Whole Genome Duplication. PLoS Comput Biol 10: e1003754. - PMC - PubMed
    1. Chen W-H, Trachana K, Lercher MJ, Bork P (2012) Younger Genes Are Less Likely to Be Essential than Older Genes, and Duplicates Are Less Likely to Be Essential than Singletons of the Same Age. Mol Biol Evol 29: 1703–1706. - PMC - PubMed
    1. Su Z, Gu X (2008) Predicting the proportion of essential genes in mouse duplicates based on biased mouse knockout genes. J Mol Evol 67: 705–709. - PubMed
    1. Makino T, Hokamp K, McLysaght A (2009) The complex relationship of gene duplication and essentiality. Trends Genet 25: 152–155. - PubMed

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