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Comment
. 2014 Aug;86(2):232-4.
doi: 10.1038/ki.2014.24.

Vitamin K and cardiovascular calcification in CKD: is patient supplementation on the horizon?

Maurizio Gallieni  1 , Maria Fusaro  2
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Free article
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Vitamin K and cardiovascular calcification in CKD: is patient supplementation on the horizon?

Maurizio Gallieni et al. Kidney Int. 2014 Aug.
Free article

Abstract

The vitamin K-dependent proteins (VKDPs) matrix Gla protein and osteocalcin protect from cardiovascular calcifications and bone fractures. A vitamin K recycling system maintains sufficient vitamin K levels for activation of VKDPs through γ-glutamyl carboxylase (GGCX). Kaesler et al. demonstrate that uremia per se can interfere with GGCX activity, contributing to vitamin K deficiency in chronic kidney disease and opening the path to the clinical use of vitamin K, currently tested in randomized trials.

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