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Comment
. 2014 Aug 14;512(7513):143-4.
doi: 10.1038/nature13650. Epub 2014 Jul 30.

Cancer: One cell at a time

Edward J Fox  1 , Lawrence A Loeb  2
Affiliations
Comment

Cancer: One cell at a time

Edward J Fox et al. Nature. .

Abstract

Single-cell DNA sequencing of two breast-cancer types has shown extensive mutational variation in individual tumours, confirming that generation of genetic diversity may be inherent in how tumours evolve.

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Figures

Figure 1
Figure 1
The genetic characteristics of cancers vary between patients, between primary and metastatic tumours in a single patient, and between the individual cells of a tumour. Wang et al. present a single-cell, whole-genome sequencing technique that will allow a better understanding of genetic heterogeneity within individual tumours.
See this image and copyright information in PMC

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References

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