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Review
. 2015 Apr 17;4(4):358-64.
doi: 10.1021/sb500258b. Epub 2014 Aug 13.

Synthetic microbes as drug delivery systems

Jan Claesen  1 , Michael A Fischbach  1
Affiliations
Review

Synthetic microbes as drug delivery systems

Jan Claesen et al. ACS Synth Biol. .

Abstract

Synthetic cell therapy is a field that has broad potential for future applications in human disease treatment. Next generation therapies will consist of engineered bacterial strains capable of diagnosing disease, producing and delivering therapeutics, and controlling their numbers to meet containment and safety concerns. A thorough understanding of the microbial ecology of the human body and the interaction of the microbes with the immune system will benefit the choice of an appropriate chassis that engrafts stably and interacts productively with the resident community in specific body niches.

Keywords: bacterial therapeutic; biosafety; delivery; diagnosis; human microbiome; signal integration.

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Figures

Figure 1
Figure 1
Features of an autonomous synthetic bacterial “physician”.
See this image and copyright information in PMC

References

    1. Lu T. K.; Collins J. J. (2007) Dispersing biofilms with engineered enzymatic bacteriophage. Proc. Natl. Acad. Sci. U.S.A. 104, 11197–11202. - PMC - PubMed
    1. Lu T. K.; Collins J. J. (2009) Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy. Proc. Natl. Acad. Sci. U.S.A. 106, 4629–4634. - PMC - PubMed
    1. Chen D. J.; Osterrieder N.; Metzger S. M.; Buckles E.; Doody A. M.; DeLisa M. P.; Putnam D. (2010) Delivery of foreign antigens by engineered outer membrane vesicle vaccines. Proc. Natl. Acad. Sci. U.S.A. 107, 3099–3104. - PMC - PubMed
    1. Xie Z.; Wroblewska L.; Prochazka L.; Weiss R.; Benenson Y. (2011) Multi-Input RNAi-Based Logic Circuit for Identification of Specific Cancer Cells. Science 333, 1307–1311. - PubMed
    1. Hamady Z. Z. R.; Scott N.; Farrar M. D.; Lodge J. P. A.; Holland K. T.; Whitehead T.; Carding S. R. (2010) Xylan-regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium Bacteroides ovatus. Gut 59, 461–469. - PubMed

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