doi: 10.1002/prot.340050405.
A protein structural motif that bends DNA
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- PMID: 2508086
- DOI: 10.1002/prot.340050405
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A protein structural motif that bends DNA
Proteins.
1989.
Abstract
The prokaryotic protein HU, integration host factor (IHF) from Escherichia coli, and transcription factor 1 (TF1) from bacteriophage SPO1 are closely related molecules. Biochemical results suggest that the role of these proteins is to bind and bend DNA. From the high-resolution structure of HU, we propose a model for this interaction with DNA. Crucial amino acid differences between the proteins can be rationalized in terms of their different specific functions.
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