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. 1989 Oct;86(19):7520-1.
doi: 10.1073/pnas.86.19.7520.

Fruit flies with additional expression of the elongation factor EF-1 alpha live longer

J C Shepherd  1 , U Walldorf, P Hug, W J Gehring
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Fruit flies with additional expression of the elongation factor EF-1 alpha live longer

J C Shepherd et al. Proc Natl Acad Sci U S A. 1989 Oct.

Abstract

In Drosophila melanogaster, the decrease in protein synthesis that accompanies aging is preceded by a decrease in elongation factor EF-1 alpha protein and mRNA. Here we show that Drosophila transformed with a P-element vector containing an EF-1 alpha gene under control of hsp70 regulatory sequences have a longer life-span than control flies.

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