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Editorial
. 2015 Jan 15;211(2):169-71.
doi: 10.1093/infdis/jiu419. Epub 2014 Jul 31.

Restimulating interest in cytomegalovirus as a cofactor for HIV infection

Vincent C Emery  1
Affiliations
Editorial

Restimulating interest in cytomegalovirus as a cofactor for HIV infection

Vincent C Emery. J Infect Dis. .
No abstract available

Keywords: cell entry; cofactors; herpesvirus; molecular mechanism; retrovirus.

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Figures

Figure 1.
Figure 1.
Potential mechanisms by which cytomegalovirus (CMV) might enhance human immunodeficiency virus (HIV) replication. Direct coinfection in cells such as macrophages could lead to enhanced HIV replication, through transactivation of the HIV long terminal repeat (LTR), or to enhanced HIV tropism, through pseudotype formation. Alternatively, CMV infection can lead to the production of the CMV G-coupled receptor US28 or its Fc receptor, leading to entry of HIV into cells that are normally not permissive. The bottom panel captures the data presented by Johnson et al (submitted), whereby CMV infection of macrophages leads to the activation of resting cord blood mononuclear cells, resulting in upregulation of CCR5, enhanced HIV entry, and increased HIV replication. Abbreviation: CBMC, cord blood mononuclear cell.
See this image and copyright information in PMC

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References

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