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Comment
. 2014 Jul 31;124(5):673-5.
doi: 10.1182/blood-2014-06-578971.

Innate protection from graft-versus-host disease

Tom Cupedo  1
Affiliations
Comment

Innate protection from graft-versus-host disease

Tom Cupedo. Blood. .

Abstract

n this issue of Blood, Hazenberg and Spits provide a detailed overview of human innate lymphoid cell (ILC) subsets and their development and distribution throughout the human body, discussing these cells in the context of human disease. In the same issue, Munneke et al for the first time link ILCs to human hematopoietic malignancies by identifying a clear correlation between the presence of activated ILCs after induction chemotherapy and the absence of acute graft-versus-host disease (GVHD) development following subsequent hematopoietic stem cell transplantation (HSCT).

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Figures

None
Activated ILCs are correlated with less GVHD. After induction chemotherapy, prior to HSCT, most ILCs are depleted. However, the remaining ILCs can have either an activated or naïve phenotype. Patients with mostly activated ILCs had a significantly lower incidence of GVHD after transplant.
See this image and copyright information in PMC

Comment on

References

    1. Hazenberg MD, Spits H. Human innate lymphoid cells. Blood. 2014;124(5):700–709. - PubMed
    1. Munneke JM, Björklund AT, Mjösberg JM, et al. Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease. Blood. 2014;124(5):812–821. - PubMed
    1. Spits H, Artis D, Colonna M, et al. Innate lymphoid cells—a proposal for uniform nomenclature. Nat Rev Immunol. 2013;13(2):145–149. - PubMed
    1. Cornelissen F, Aparicio Domingo P, Reijmers RM, Cupedo T. Activation and effector functions of human RORC+ innate lymphoid cells. Curr Opin Immunol. 2011;23(3):361–367. - PubMed
    1. Cella M, Fuchs A, Vermi W, et al. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature. 2009;457(7230):722–725. - PMC - PubMed