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. 2014 May 29:3:e28976.
doi: 10.4161/onci.28976. eCollection 2014.

Tertiary lymphoid structures in human lung cancers, a new driver of antitumor immune responses

Jérémy Goc  1 , Wolf-Herman Fridman  1 , Scott A Hammond  2 , Catherine Sautès-Fridman  1 , Marie-Caroline Dieu-Nosjean  1
Affiliations

Tertiary lymphoid structures in human lung cancers, a new driver of antitumor immune responses

Jérémy Goc et al. Oncoimmunology. .

Abstract

T-cell infiltrates are robust prognostic biomarkers in the majority of human cancers. However, the mechanisms that shape a protective T-cell response remain unclear. Our recent study implicates tertiary lymphoid structures in the shaping of an efficient and beneficial immune response in lung cancer patients.

Keywords: dendritic cell; lung cancer; tertiary lymphoid structure; tumor immunology; tumor-infiltrating lymphocyte.

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Figures

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Figure 1. Cancer-associated tertiary lymphoid structures drive antitumor immune responses. In the lung tumor microenvironment, the presence of tertiary lymphoid structures (TLS) may foster the immigration of immune cells via high endothelial venules (HEVs), thereby promoting a protective cellular immune response that ultimately positively affects the clinical outcome of cancer patients.
See this image and copyright information in PMC

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