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Comment
. 2014 Jul 31;158(3):477-8.
doi: 10.1016/j.cell.2014.07.010.

microManaging mitochondrial translation

Jessica Nouws  1 , Gerald S Shadel  2
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microManaging mitochondrial translation

Jessica Nouws et al. Cell. .
Free article

Abstract

Regulation of gene expression in mammalian mitochondria by microRNAs is reported by Zhang et al. During muscle cell differentiation, localization of a miRNA is increased within mitochondria, where it interacts with Ago2 to selectively activate translation of mtDNA-encoded mRNAs. The findings represent a new mitochondrial regulatory pathway and a potentially powerful means to purposefully manipulate mtDNA expression.

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