Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Aug 3:12:219.
doi: 10.1186/s12967-014-0219-9.

Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases

Stefania Bulotta, Marilena Celano, Saverio Massimo Lepore, Tiziana Montalcini, Arturo Pujia  1 , Diego Russo
Affiliations
Review

Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases

Stefania Bulotta et al. J Transl Med. .

Abstract

The overall health beneficial action of olive oil phenolic components is well established. Recent studies have elucidated the biological effects of two isolated compounds, namely oleuropein and hydroxytyrosol, with particular attention on their antioxidant activity. Thus, a protective action has been demonstrated in preclinical studies against several diseases, especially cardiovascular and metabolic disorders. The present review will describe the biological effects of oleuropein and hydroxytyrosol, with particular attention on the molecular mechanism underlying the protective action on cardiovascular and metabolic alterations, as demonstrated by in vitro and in vivo experimental studies performed with the isolated compounds.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Composition of unsaponifiable and saponifiable fractions of olive oil.
Figure 2
Figure 2
Chemical structure of the best known phenolic compounds in the VOO.
Figure 3
Figure 3
Antioxidant activity and related effects of oleuropein and hydroxytyrosol.
See this image and copyright information in PMC

References

    1. Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A, Helsing E, Trichopoulos D. Mediterranean diet pyramid: a cultural model for healthy eating. Am J Clin Nutr. 1995;61(Suppl 6):1402S–1406S. - PubMed
    1. Tripoli E, Giammanco M, Tabacchi G, Di Majo D, Giammanco S, La Guardia M. The phenolic compounds of olive oil: structure, biological activity and beneficial effects on human health. Nutr Res Rev. 2005;18:98–112. - PubMed
    1. Huang C, Sumpio B. Olive oil, the mediterranean diet, and cardiovascular health. J Am Coll Surg. 2008;207:407–416. - PubMed
    1. García-González DL, Aparicio-Ruiz R, Aparicio R. Virgin olive oil – chemical implications on quality and health. Eur J Lipid Sci Technol. 2008;110:602–607.
    1. Omar SH. Oleuropein in olive and its pharmacological effects. Sci Pharm. 2010;78:133–154. - PMC - PubMed

Publication types

MeSH terms