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. 2014 Nov 17;53(47):12676-94.
doi: 10.1002/anie.201402380. Epub 2014 Aug 1.

The principle of membrane fusion in the cell (Nobel lecture)

James Edward Rothman  1
Affiliations

The principle of membrane fusion in the cell (Nobel lecture)

James Edward Rothman. Angew Chem Int Ed Engl. .

Abstract

Cells contain small membrane-enclosed vesicles which transport many kinds of cargo between the compartments of the cell. The result is a choreographed program of secretory, biosynthetic, and endocytic protein traffic that serves the cell's internal physiologic needs.

Keywords: Nobel lecture; SNARE; cellular biology; membrane fusion; vesicle transport.

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