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. 2015 Feb 2;54(6):1910-3.
doi: 10.1002/anie.201405252. Epub 2014 Aug 1.

Enantioselective formation of all-carbon quaternary stereocenters from indoles and tertiary alcohols bearing a directing group

Wanxiang Zhao  1 , Zhaobin Wang, Boyang Chu, Jianwei Sun
Affiliations

Enantioselective formation of all-carbon quaternary stereocenters from indoles and tertiary alcohols bearing a directing group

Wanxiang Zhao et al. Angew Chem Int Ed Engl. .

Abstract

Described is an efficient catalytic asymmetric intermolecular C-C bond-formation process to generate acyclic all-carbon quaternary stereocenters. The reactions overcome the unfavorable steric hindrance around reactive centers, and the competitive elimination (E1), to form a range of useful indole products with excellent efficiency and enantioselectivity.

Keywords: asymmetric catalysis; enantioselectivity; heterocycles; organocatalysis; synthetic methods.

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