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Review
. 2014:2014:452737.
doi: 10.1155/2014/452737. Epub 2014 Jun 24.

Is bisphosphonate-related osteonecrosis of the jaw an infection? A histological and microbiological ten-year summary

A M Hinson  1 , C W Smith  2 , E R Siegel  3 , B C Stack Jr  4
Affiliations
Review

Is bisphosphonate-related osteonecrosis of the jaw an infection? A histological and microbiological ten-year summary

A M Hinson et al. Int J Dent. 2014.

Abstract

The role of infection in the etiology of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is poorly understood. Large-scale epidemiological descriptions of the histology and microbiology of BRONJ are not found in the literature. Herein, we present a systematic review of BRONJ histology and microbiology (including demographics, immunocompromised associations, clinical signs and symptoms, disease severity, antibiotic and surgical treatments, and recovery status) validating that infection should still be considered a prime component in the multifactorial disease.

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Figures

Figure 1
Figure 1
Published articles (n = 55) containing histological and microbiological data from January 2003 to December 2013.
Figure 2
Figure 2
Immunosuppressed association (a) and clinical presentation (b) of the BRONJ population (n = 814).
Figure 3
Figure 3
Histological results (a), microscopic identification of Actinomyces by H&E, Gram, and/or PAS stains (b), and culture results excluding Actinomyces (c).
See this image and copyright information in PMC

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