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. 2014 Aug;4(4):221-5.
doi: 10.1007/s13659-014-0030-6. Epub 2014 Jul 17.

Carinatines A and B, Lycopodium Alkaloids from Phlegmariurus carinatus

Fei Liu  1 , Yu-Cheng Liu  1 , Wei-Wei Jiang  1 , Juan He  2 , Xing-De Wu  2 , Li-Yan Peng  2 , Jia Su  2 , Xiao Cheng  2 , Qin-Shi Zhao  2
Affiliations

Carinatines A and B, Lycopodium Alkaloids from Phlegmariurus carinatus

Fei Liu et al. Nat Prod Bioprospect. 2014 Aug.

Abstract

Carinatine A (1), a C16N2-type Lycopodium alkaloid possessing a 5/6/6/6 ring system formed by a new C-4/C-12 bond, and carinatine B (2), the first derivative of lycojaponicumin C, along 16 known compounds, were isolated from the whole plant of Phlegmariurus carinatus. Their structures were elucidated based on the spectroscopic data. The two new isolates were no inhibitory activity for the acetylcholinesterase (AChE).

Keywords: Acetylcholinesterase (AChE) inhibitory activity; Carinatines A and B; Lycopodium alkaloid; Phlegmariurus carinatus.

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Figures

Fig. 1
Fig. 1
Chemical structures of isolated compounds 1–2
Fig. 2
Fig. 2
Selected 2D NMR correlations for carinatine A (1)
Fig. 3
Fig. 3
Selected 2D NMR correlations for carinatine B (2)
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