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Review
. 2014;10(2):149-55.

Oncogenic osteomalacia induced by a sinonasal tumour: case report and review

H Kabtouri, R Karmali, L Spinato, M Khamaktchian, P Bisschop
  • PMID: 25090814
Review

Oncogenic osteomalacia induced by a sinonasal tumour: case report and review

H Kabtouri et al. B-ENT. 2014.

Abstract

Background: Oncogenic osteomalacia (OOM) is a rare paraneoplastic syndrome characterized by hypophosphatemia and overexpression of a phosphaturic agent, fibroblast growth factor 23 (FGF23). OOM is associated with a variety of mesenchymal tumours referred to as phosphaturic mesenchymal tumours. Head and neck regions are concerned in 5-10% of cases.

Methods and results: We report the case of a 42-year-old female with OOM caused by a hemangiopericytoma of the left ethmoid sinus. The period between first symptoms and surgical excision of the lesion was approximately 5 years. We also conducted a PubMed-based search to identify all cases of OOM related to sinonasal tumour. Twenty eight cases in the sinonasal area were reported in the literature.

Conclusion: OOM is an important diagnosis because resection of the causative tumour results in cure of the disease.

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