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. 1989 Jul;37(7):1813-5.
doi: 10.1248/cpb.37.1813.

Structure-activity correlation of flavonoids for inhibition of bovine lens aldose reductase

M Iinuma, T Tanaka, M Mizuno, T Katsuzaki, H Ogawa

Structure-activity correlation of flavonoids for inhibition of bovine lens aldose reductase

M Iinuma et al. Chem Pharm Bull (Tokyo). 1989 Jul.

Abstract

To clarify the structure-activity correlation of flavonoids for inhibition of aldose reductase, about fifty flavonoid compounds were screened. The presence of hydrophobic substituents on the A ring and hydrophilic substituents on the B ring of the flavonoid skeleton was suggested to improve the potency of inhibitory activity. The activities of extracts of Scutellaria baicalensis, Andrographis paniculata and Gutierrezia microcephala are also described.

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