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Comment
. 2014 Aug;4(8):870-2.
doi: 10.1158/2159-8290.CD-14-0628.

The democratization of the oncogene

Anh T Le  1 , Robert C Doebele  2
Affiliations
Comment

The democratization of the oncogene

Anh T Le et al. Cancer Discov. 2014 Aug.

Abstract

The identification of novel, oncogenic gene rearrangements in inflammatory myofibroblastic tumor demonstrates the potential of next-generation sequencing (NGS) platforms for the detection of therapeutically relevant oncogenes across multiple tumor types, but raises significant questions relating to the investigation of targeted therapies in this new era of widespread NGS testing.

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Conflict of interest statement

Disclosures: No conflicts of interest to declare for ATL.

Figures

Figure 1
Figure 1. A variety of ROS1 gene fusions occur across multiple tumor types
(A) Schematic of oncogenic ROS1 fusions identified to date, illustrating 20 different 5’ gene fusion partners that rearrange with ROS1 in cancer. (B) Illustration of tumor types identified thus far that can harbor ROS1 gene fusions.
See this image and copyright information in PMC

Comment on

References

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