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. 2014 Dec;33(12):1222-5.
doi: 10.1097/INF.0000000000000456.

Severe parechovirus infection in Norwegian infants

Marius K Skram  1 , Lars H Skanke, Sidsel Krokstad, Svein A Nordbø, Lutz Nietsch, Henrik Døllner
Affiliations

Severe parechovirus infection in Norwegian infants

Marius K Skram et al. Pediatr Infect Dis J. 2014 Dec.

Erratum in

  • Pediatr Infect Dis J. 2015 Mar;34(3):295

Abstract

Background: Human parechovirus genotype 3 (HPeV-3) has been linked to meningoencephalitis and sepsis-like disease in infants younger than 3 months.

Methods: We present clinical and phylogenetic characteristics of 15 infants who were admitted with HPeV-3 infections to 3 hospitals in Norway during a period of 7 months in 2011.

Results: Eleven patients had a sepsis-like disease, and meningoencephalitis was found in 10. Phylogenetic analyses of the viral protein (VP)3/VP1 region showed that all HPeV-3 isolates clustered closely and differentially from previously known HPeV-3 lineages. Fourteen of the 15 infants recovered after 1-3 weeks. One boy had widespread cerebral magnetic resonance imaging abnormalities, but at 1 year of age he had a normal psychomotor status.

Conclusion: A new HPeV-3-strain caused sepsis-like disease and meningoencephalitis in 15 Norwegian infants. All but 1 recovered within a few weeks.

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