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Review
. 2014 Sep;30(9):401-7.
doi: 10.1016/j.tig.2014.07.003. Epub 2014 Aug 3.

Whole-genome sequencing to control antimicrobial resistance

Claudio U Köser  1 , Matthew J Ellington  2 , Sharon J Peacock  3
Affiliations
Review

Whole-genome sequencing to control antimicrobial resistance

Claudio U Köser et al. Trends Genet. 2014 Sep.

Abstract

Following recent improvements in sequencing technologies, whole-genome sequencing (WGS) is positioned to become an essential tool in the control of antibiotic resistance, a major threat in modern healthcare. WGS has already found numerous applications in this area, ranging from the development of novel antibiotics and diagnostic tests through to antibiotic stewardship of currently available drugs via surveillance and the elucidation of the factors that allow the emergence and persistence of resistance. Numerous proof-of-principle studies have also highlighted the value of WGS as a tool for day-to-day infection control and, for some pathogens, as a primary diagnostic tool to detect antibiotic resistance. However, appropriate data analysis platforms will need to be developed before routine WGS can be introduced on a large scale.

Keywords: antibiotic resistance; diagnostics; surveillance; whole-genome sequencing.

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References

    1. Centers for Disease Control and Prevention . US Department of Health and Human Services; 2013. Antibiotic Resistance Threats in the United States, 2013.
    1. Davies S.C. In: Annual Report of the Chief Medical Officer. Volume II: Infections and the Rise of Antibiotic Resistance. Walker D., Fowler T., editors. The Stationery Office; 2011.
    1. WHO . World Health Organization; 2012. The Evolving Threat of Antimicrobial Resistance – Options for Action.
    1. Livermore D.M., Wain J. Revolutionising bacteriology to improve treatment outcomes and antibiotic stewardship. Infect. Chemother. 2013;45:1–10. - PMC - PubMed
    1. Spellberg B. The future of antibiotics and resistance. N. Engl. J. Med. 2013;368:299–302. - PMC - PubMed

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