Accuracy of multidetector-row CT in diagnosing lymph node metastasis in patients with gastric cancer

Abstract

Objectives: The purpose of this study was to determine the optimal cut-off value of lymph node size for diagnosing metastasis in gastric cancer with multidetector-row computed tomography (MDCT) after categorizing perigastric lymph nodes into three regions.

Methods: The study included 90 gastric cancer patients who underwent gastrectomy. The long-axis diameter (LAD) and short-axis diameter (SAD) of all visualized lymph nodes were measured with transverse MDCT images. The locations of lymph nodes were categorized into three regions: lesser curvature, greater curvature, and suprapancreatic. The diagnostic value of lymph node metastasis was assessed with receiver operating characteristic (ROC) analysis.

Results: The area under the curve was larger for SAD than LAD in all groups. The optimal cut-off values of SAD were determined as follows: overall, 9 mm; differentiated type, 9 mm; undifferentiated type, 8 mm; lesser curvature region, 7 mm; greater curvature region, 6 mm; and suprapancreatic region, 9 mm. The diagnostic accuracies for lymph node metastasis using individual cut-off values were 71.1% based on histological type and 76.6% based on region of lymph node location.

Conclusions: The diagnostic accuracy of lymph node metastasis in gastric cancer was improved by using individual cut-off values for each lymph node region.

Key points: • Multidetector-row computed tomography is widely used to predict pathological nodal status. • An optimal cut-off value of lymph node size has not been determined. • Cut-off values were assessed according to histology and nodal location. • The optimal cut-off values differed based on histology and nodal location. • Diagnostic accuracy was improved by using individual cut-off values for each region.