Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jul-Aug;46(4):430-2.
doi: 10.4103/0253-7613.135958.

Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro

Ivan S Ivanov  1 , Anastasia V Sidehmenova  1 , Vera I Smol'yakova  1 , Galina A Chernysheva  1 , Mark B Plotnikov  2
Affiliations

Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro

Ivan S Ivanov et al. Indian J Pharmacol. 2014 Jul-Aug.

Abstract

Objectives: To investigate the antiplatelet activity of alpha-lipoic acid (α-LA) and dihydroquercetin (DHQ).

Methods: Antiplatelet activity of the α-LA and DHQ was evaluated in rich platelet plasma of rat. The platelet aggregation was induced by adenosine diphosphate (ADP) in concentration of 4 × 10(-5) M.

Results: α-LA and DHQ inhibited platelet aggregation in concentration-dependent manner. The antiplatelet activity of α-LA was more pronounced than DHQ. DHQ also increased the antiplatelet activity of α-LA by 1.4 times.

Conclusion: Combined simultaneous use of α-LA and DHQ possessed the high antiplatelet activity, and DHQ potentiated the activity of α-LA.

Keywords: Alpha-lipoic acid; antioxidants; antiplatelet activity; dihydroquercetin; platelet aggregation.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: No

Similar articles

See all similar articles

Cited by

References

    1. Cushman M. Epidemiology and risk factors for venous thrombosis. Semin Hematol. 2007;44:62–9. - PMC - PubMed
    1. Preston FE, Greaves M. Thrombotic vascular disease. Br J Hosp Med. 1985;34:46–50. - PubMed
    1. Kumar A, Kao J. Platelet resistance to antiplatelet drugs. Recent Pat Cardiovasc Drug Discov. 2009;4:98–108. - PubMed
    1. Gadi D, Bnouham M, Aziz M, Ziyyat A, Legssyer A, Bruel A, et al. Flavonoids purified from parsley inhibit human blood platelet aggregation and adhesion to collagen under flow. J Complement Integr Med. 2012;9 >Article 19. - PubMed
    1. Bilska A, Włodek L. Lipoic acid-the drug of the future? Pharmacol Rep. 2005;57:570–7. - PubMed